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DEPARTMENT OF DEVELOPMENTAL BIOLOGY:
 

Departmental Research Activities

Research activities in the Department of Developmental Biology range from basic to clinical research. The basic research can be divided into seven areas.

1) Early embryonic and craniofacial development – W. Chen, M. Levin, Y-P. Li, P. Yelick
2) Bone and cartilage development and growth – W. Chen, L. Gamer, P.V. Hauschka, B. Lanske, B.R. Olsen, V. Rosen, P. Stashenko
3) Tooth development and tissue engineering – J.D. Bartlett, H. Margolis, B.R. Olsen, P. Yelick
4) Bone and cartilage remodeling, repair and disease – W. Chen, P.V. Hauschka, Y. Li, Y-P. Li, B.R. Olsen, V. Rosen, P. Stashenko, L. Xu
5) Vascular development and pathology – E. Boye, B.R. Olsen
6) Oral immunology and immune mediated oral disease – T. Kawai, P. Stashenko, M. Taubman
7) Oral microbiology and microbial disease – F.E. Dewhirst, B. Paster

In clinical research, Dr. D.B. Giddon has developed and utilizes new methods for studying perception of facial esthetics, Dr. H.L. Needleman studies safety and efficacy of methods for sedating children for dental procedures, nocturnal bruxism in children and adolescents, and pain associated with dental rehabilitations, and Dr. L.A. Will studies clinical aspects of palatal implants, directs orofacial cleft outcome studies, and participates in a collaborative linkage study of familial early onset periodontitis.

A Program Project grant entitled “Molecular and Cellular Mechanisms of Vascular Anomalies,” has been awarded by NIH/NIAMS. This program (P.I. B.R. Olsen) is a collaborative effort among three research groups (those of Drs. J. Bischoff and Olsen in Boston and Dr. M. Vikkula in Brussels), and two plastic surgeons (Dr. J. Mulliken in Boston and Dr. L. Boon in Brussels). The two clinical centers involved are the Vascular Anomalies Center at the Children’s Hospital in Boston and the Vascular Anomalies Center at Cliniques Universitaires St. Luc, Catholic University of Louvain, in Brussels. These centers are pre-eminent worldwide for treatment of patients with hemangiomas and vascular malformations.
   

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