#  Guest Lecture: Osteoimmunology—Abnormal bone resorption and formation in inflammation 

 



    ![bone cells](/sites/g/files/omnuum6001/files/styles/hwp_5_4__480x385/public/2025-04/osteoclast.jpg?itok=GzEUa97K) 

 



 

####  calendar\_today Date and Time 

 **April 23, 2025** 

 04:00PM - 05:30PM EDT 

####  pin\_drop Location 

 **REB Auditorium or Zoom**  



 

 [ Register arrow\_circle\_right ](https://harvard.zoom.us/webinar/register/WN_CnJcBgwPReuJZWf2yOokNg) 

 



 

## Overview

Join us for a special guest lecture by Dr. Hiroshi Takayanagi, a leading researcher in the field of osteoimmunology—a discipline that explores the complex interactions between the immune and skeletal systems.

In this talk, Dr. Takayanagi will explore mechanisms of bone destruction and formation in inflammatory diseases such as rheumatoid arthritis. He will share recent findings on the role of RANKL-expressing synovial fibroblasts, the transcription factor ETS1, and novel insights into Activin-producing macrophages that contribute to both muscle regeneration and ectopic bone formation. His presentation will also highlight the emerging field of stromal immunology, shedding light on how mesenchymal cells like synovial fibroblasts influence immune responses and tissue remodeling.

Don't miss this opportunity to gain insights into the molecular pathways that drive abnormal bone resorption and formation in inflammatory disease.

### About the speaker

   ![Dr Hiroshi Takayanagi headshot](/sites/g/files/omnuum6001/files/styles/hwp_1_1__360x360_scale/public/2025-04/Hiroshi_Takayanagi.jpg?itok=YCya0Nv3) 

 

Dr. Hiroshi Takayanagi began his career as an orthopedic surgeon specializing in the treatment of rheumatoid arthritis after graduating from the University of Tokyo. He became a professor at Tokyo Medical and Dental University in 2003, where he focused on autoimmune diseases and the emerging field of osteoimmunology. Since 2012, he has served as Professor in the Department of Immunology at the University of Tokyo’s Graduate School of Medicine. His research interests span T cell development, immune tolerance, osteoclast biology, and musculoskeletal diseases. More recently, his work has expanded into stromal immunology and stromal cell-mediated cancer protection.



 

 



 

 See also:- [ Homepage ](/home-page/homepage)
- [ Research ](/event-categories/research)
 
 

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